Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
USERS' SCORE
Good
Based on 30 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
MethylSulfonylMethane (MSM)
1,000 mg
†
Top Medical Research Studies
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
Most Useful Reviews
9
Positive impact
28 people found this helpful
I find it beneficial and it doesn't harm. I purchased it for my father who suffers from knee pain. Please keep him in your prayers. The taste isn't pleasant, but the quality is satisfactory.
Read More
9
Benefits my father
4 people found this helpful
I find it beneficial and poses no harm. I ordered it for my father, who experiences knee pain. Please keep him in your prayers. The taste is quite poor, but the quality is acceptable.
Read More
10
Positive impact
2 people found this helpful
A like benefits me and does not harm you. I bought it for my father who has knee problems. Please pray for him. The taste is not great, but the quality is satisfactory.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
- All Researches
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Read More
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 30 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Positive impact
28 people found this helpful
I find it beneficial and it doesn't harm. I purchased it for my father who suffers from knee pain. Please keep him in your prayers. The taste isn't pleasant, but the quality is satisfactory.
Read More
9
Benefits my father
4 people found this helpful
I find it beneficial and poses no harm. I ordered it for my father, who experiences knee pain. Please keep him in your prayers. The taste is quite poor, but the quality is acceptable.
Read More
10
Positive impact
2 people found this helpful
A like benefits me and does not harm you. I bought it for my father who has knee problems. Please pray for him. The taste is not great, but the quality is satisfactory.
Read More
9
Positive impact
2 people found this helpful
A like benefits me and does not harm you. I ordered it for my father who has knee problems. Your prayers for him are appreciated. The taste is not good, but the quality is decent.
Read More
9
Quality product
2 people found this helpful
It benefits me and does not harm you. I ordered it for my father, who has knee problems. Please pray for him. The taste is not good, yet the quality is satisfactory.
Read More
Frequently Asked Questions
9
Positive impact
28 people found this helpful
I find it beneficial and it doesn't harm. I purchased it for my father who suffers from knee pain. Please keep him in your prayers. The taste isn't pleasant, but the quality is satisfactory.
9
Relief for knees
1 people found this helpful
It benefits me and does no harm. I bought it for my father, who has knee problems. Please pray for him. While the taste is subpar, the quality remains good.
9
Benefits my father
4 people found this helpful
I find it beneficial and poses no harm. I ordered it for my father, who experiences knee pain. Please keep him in your prayers. The taste is quite poor, but the quality is acceptable.
9
Supports my father
2 people found this helpful
It benefits me and is not harmful. I bought it for my father, who suffers from knee problems. Please pray for him. The flavour isn't pleasant, but the quality is acceptable.
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
References
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15132995
- Tennent DJ, Hylden CM, Kocher BK, Aden JK, Johnson AE. A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees. US Army Med Dep J. 2017.
- Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, et al. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013;12:154. doi:10.1186/1475-2891-12-154
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. doi:10.1186/1472-6882-11-50
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
